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Information × Registration Number 0213U003127, 0111U002154 , R & D reports Title The role of single nucleotide polymorphism of MGP gene in the development of sclerotic lessions of blood vessels popup.stage_title Head Ataman Alexander Vasilievich, Registration Date 24-01-2013 Organization Sumy State University popup.description2 The association of gene MGP polymorphisms (T-138C, G-7A i Thr83Ala) and acute coronary syndrome (ACS) in the Ukrainian population was studied. In patients with ACS, A/A variant of the promoter (G-7A polymorphism) occurs 3.4 times frequently than in healthy donors. The relationship between genotype and ACS is associated with sexs: females homozygous for the minor allele A/A (G-7A polymorphism gene MGP) occurs 5.6 times more often than women carrying the main allele (G/A and G/G). The association of the studied polymorphisms with risk factors for acute coronary syndrome was found: among carriers of A/A genotype, ACS occurs more frequently in individuals with BMI ? 25kh/m2 and hypertension. Product Description popup.authors Атаман Юрій Олександрович Бороденко Анастасія Олександрівна Гарбузова Вікторія Юріївна Дубовик Євген Іванович Кіндя Валерій Ілліч Мазур Тетяна Станіславівна Смірнов Олег Ювеналійович Янчик Галина Володимирівна popup.nrat_date 2020-04-02 Close