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Information × Registration Number 0213U003892, 0109U007155 , R & D reports Title Investigation of the combined action of exogenous nitric oxides and low doses of ionizing radiation on balance of free-radical processes, development of genetic instability and increase of cancer risk. popup.stage_title Head Mikhailenko Victor Mikhailovich, Registration Date 06-02-2013 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 For the first time shown that the integral effect of exogenous nitrogen oxides combined with low doses of ionizing radiation in the development of free radical pathology caused mainly nitrogen oxides. Prolonged inhalation intake of nitrogen oxides compared with the effect of low doses of radiation caused significant changes in metabolism of animal tissue: accumulation of oxidation products (malonic dyaldehid), deregulation of antioxidant enzymes (superoxide dismutase, catalase), impaired generation of superoxide radical and increase of genetic damage that determines its leading role in development of genomic instability. The development of oxidative stress, increased genotoxic effect and formation of genome instability in cells with the depleted potential of stem marrow hematopoiesis indicate increased carcinogenic risk caused by combined action of nitric oxide and ionizing radiation. Product Description popup.authors Єлейко-Хемич Любомира Олегівна Ганжа Олена Борисівна Геращенко Богдан Іванович Главін Олексій Анатолійович Демченко Олена Миколаївна Дружина Микола Олександрович Дьоміна Емілія Анатоліївна Клепець Леонід Федосєєвіч Маковецька Людмила Ігорівна Музальов Іван Іванович Родіонова Наталія Костянтинівна Рябченко Наталія Миколаївна popup.nrat_date 2020-04-02 Close