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Information × Registration Number 0213U005810, 0110U000543 , R & D reports Title Identification of the molecular structures determinated ongoing activity of retinal cells. popup.stage_title Head Fedulova Svitlana A., Registration Date 25-07-2013 Organization International center of molecular physiology popup.description2 Characteristics of 4 aminopyridine-sensitive potassium current in the rat retinal ganglion cells were studied using whole cell patch-clamp techniques. Application of potassium channels blocker 4-aminopyridine (0,2 mM) reduced potassium current amplitude in the retinal neurons. The mean value of 4-aminopyridine-sensitive current was equal to 0,40 ± 0,09 nА (n = 6), this was 25% from the control current (1,61 ± 0,22 nA, n = 6). The 4-aminopyridine-sensitive current characteristics (activation threshold, fast activation and deactivation, slow inactivation) were similar to Kv3.1/Kv3.2 potassium currents described in the literature. The data obtained suggest that 4-aminopyridine-sensitive current plays a key role in high frequency firing generation in the rat retinal ganglion cells. We assume that the 4-aminopyridine-sensitive current is mediated by Kv3.1/Kv3.2 conductance Product Description popup.authors Веселовська З.Ф. Маслов В.Ю. popup.nrat_date 2020-04-02 Close