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Registration Number

0213U007178, 0110U000787 , R & D reports

Title

The developing of the methods for synthesis of nanocomposites, nanocrystals and biopolymer-gold/platinum complexes with analysis of the conditions for utilization of such nanoforms in oncotherapy and optoelectronics.

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Head

Estrela-Llopis Victorio Rafaelevich,

Registration Date

16-04-2013

Organization

F.D. Ovcharenko Institute of biocolloidal Chemistry NAS of Ukraine

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Based on complex investigations of adsorption, electrokinetics and chemical analysis it were developed new methods for synthesis of gold nanocrystals and nanocomposites of nano- gold and platinum with adsorbtion layers of polysaccharides of microalgae and doxorubicin. It was at first developed the method of water medium synthesis of gold nanopryzm-monocrystals with nearly monodisperse distribution of linear sizes (40-80 nm) and thickness (5-15 nm). It was established in experiments in vitro and in vivo the cytotoxic effects of this nanoforms on cancer cells of different oncogenesis and sarcoma-180 tumor . In comparative experiments with leukemia cells and healthy human lymphocytes it was installed selective toxicity of the synthesized nanocrystals with cancer cells (in collaboration with IEPOR NAS of Ucraine). It was established by the method of SERS and micro-Raman spectroscopy the effect of plasmon resonance amplification of the 2-4 order in the contact zone of bordering gold nanoprisms depending on their mutual orientation. This provide new opportunitis of significant enhancement of biodetection sensitivity based on the SERS method (in collaboration with IPh NAS of Ucraine).

Product Description

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А.В. Чевичалова
Бородінова Т.І.
Каганов В.Я.
Олійник А. І.
Рижук О.В.

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2020-04-02