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Registration Number

0213U008313, 0113U000262 , R & D reports

Title

To study the mechanisms of development of metabolic disorders and work out the possibility of their correction in the experimental pulmonary edema

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Head

Korzhov Vitaliy, Доктор медичних наук

Registration Date

15-01-2014

Organization

SO "National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine"

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The object is the blood of white rats with experimental pulmonary edema (PE). The purpose is to study the functional state of glutathione dependent and oxidant-antioxidant systems in experimental PE, to determine violations of various parts of these systems. The following methods are used: experimental, biochemical, histological and statistical. Under the experimental PE condition activation of lipid peroxidation, homeostasis violation of glutathione dependent enzyme system, increasing the sorption capacity of red blood cells, the accumulation of endogenous intoxication markers - the average molecular weight were established. Identified biochemical violations depend on the adrenaline dose and the times elapsed after the pathology simulation, and have a maximum intensity changes at a dose of epinephrine 1,5 mg/kg body weight. Histomorphological signs of experimental PE depending on the dose of the drug and the time of observation were defined. Sphere of application - pulmonology

Product Description

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Жадан Вікторія Миколаївна
Касьян Наталія Анатоліївна
Коржов Віталій Іванович
Лоза Тетяна Василівна
Олексинська Ольга Олександрівна

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2020-04-02