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Information × Registration Number 0214U001943, 0111U003341 , R & D reports Title Features of clinical flow, optimization of diagnostics, treatment and rehabilitation of posttravmatic epilepsy popup.stage_title Head Son Anatoliy, Registration Date 02-12-2014 Organization Odessa State Medical Universitu popup.description2 The study involved 158 rats with kindling-induced epilepsy. Investigated the behavioral, motor disorders in Wistar rats before and after treatment with modern anticonvulsant and neuroprotective drugs. The results indicate that the use of levetiracetam (LVR) eliminates the kindling-provoked anxiety and depressive behaviors. What is important for the combined treatment of anxiety and depression in patients with posttraumatic epilepsy with LWR. First experimentally investigated the therapeutic effects of combined therapy LVR and diazepam, resulting in a dose-dependent antiepileptic action. Decreases the frequency, amplitude of adhesive categories, as well as reducing the duration of the existence of foci of epileptic activity. Considering that pharmacological resistance develops in most antiepileptic drugs except LVR set an effect of mutual potentiation of anticonvulsant action of diazepam LVR and it is possible to apply the correction to the action of diazepam tolerance - including and anxiolytic activity. Product Description popup.authors Герцев Василь Миколайович Горанський Юрій Іванович Добровольський Василь Вячеславович Клаупік Люсьєна Ернестівна Лебідь Олена Павлівна Муратова Тетяна Миколаївна Муратова Тетяна Миколаївна Перькова Ганна Василіївна Солодовникова Юлія Олександрівна Сон Анатолій Сергійович Стоянов Олександр Миколайович Хрущ Олександр Володимирович Чемересюк Інна Георгієвна popup.nrat_date 2020-04-02 Close