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Information × Registration Number 0214U001946, 0111U003345 , R & D reports Title The neuropathophysiological analysis of temporal epilepsy mechanisms of development and performing out its therapy methods popup.stage_title Head Shandra Alexey Antonovich, Registration Date 02-12-2014 Organization Odesa National Medical University popup.description2 These results deepen the ideas of neuropathophysiological mechanisms of chronic epileptic activity development in conditions of pilocarpine-induced convulsive syndrome. I.p. pilocarpine (380 mg/kg) administration was shown to induce the the complex of behavioural and electrographic disturbances characteristic for the status epilepticus which is characterized by spontaneous postponed seizures development. There were shown firstly diazepam-, phenobarbital- and valproic acid antiepileptic effect in conditions of pilocarpine-induced pontaneous seizures. Diphenylhydantoin and carbamazepine failed to suppress the spontaneous postponed pilocarpine-induced seizures. Thus it was settled firstly the dose of a diazepam which prevents the pilocarpine-induced spontaneous convulsions development in 50% of rats equals to 9,64±0,98 mg/kg. The mean effective doses of phenobarbital and valproic acid were equal, respectively, to 15,53±1,54 mg/kg and 244,5±27,3 mg/kg. The development of the new therapeutic approaches that increase the efficiency of treatment and prevention of temporal epileptic activity are planned. Product Description popup.authors Вастьянов Руслан Сергійович Волохова Галина Олександрівна Герасимович Ема В’ячеславівна Денисенко Оксана Вікторівна Кащенко Ольга Анатоліївна Кириленко Наталія Анатоліїівна Копйова Надія Вікторівна Ляшенко Світлана Леонідівна Община Ніна Василівна Онуфриєнко Оксана Вікторівна Прищепа Олена Олександрівна Савченко Михайло Васильович Топал Марина Михайлівна Шандра Олексій Антонович popup.nrat_date 2020-04-02 Close