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Information × Registration Number 0214U003417, 0111U002013 , R & D reports Title Phylogenetic analyses of influenza viruses and there evolution trend popup.stage_title Head Mironenko Alla Petrovna, Registration Date 31-01-2014 Organization The L.V.Gromaschevskyi Scientific and Research Institute of Epidemiology and Infectious Diseases popup.description2 A research aim is establishing evolutional connections between the viruses of flu, distinguished in Ukraine and such that circulate in other countries of the world and directionfinding of their evolution on the basis of study of antigen and genetic descriptions. A research object is stamms of virus of flu, genetic sequences of РНК of virus of flu, amino acid sequences of proteins of virus of flu. Methods of researches - epidemiology, virologic, serum molecular-genetic, statistical. First for history of study of flu the phyllogenetic analysis of viruses of flu of people is conducted in Ukraine, and certainly them штамове variety at molecular level. Advantages of application of method are shown for the detailed description of circulatory stamms. With the use of merge technique next-door neighbours (NJ) unique phyllogenetic trees are built, where genetic similarity of the investigated isolates is set to the viruses from other countries and to the vaccine stamms. Analysed amino acid sequences and educed substitutions in гемаглютиніні and нейрамінідазі viruses of flu of people And, And(H1N1) pdm and In/Yamagata and In/Victoria. The genetic analysis of the Ukrainian viruses of flu showed absence of specific mutations with that link резистентність to preparation of оселтамівір, that confirmed their sensitiveness to this preparation. On results a genetic analysis, skidding of epidemic stamms is new-onset to Ukraine from other countries for all subtypes/of genetic lines of viruses of flu of people. The got results are inculcated in work of National Center of Flu, that is the important constituent of supervision after a flu in the world. A phyllogenetic analysis is inculcated for perfection of research of genetic changeability of causative agents of flu in a country that will help to control them and forecast appearance of new epidemic stamms. Application of phyllogenetic analysis is recommended at determination of штамового will lay down etiologic actual vaccines against a flu on every epidemic season for Ukraine. The exposure of new genetic variants of viruses of flu will do possible розробк Product Description popup.authors А. Міроненко А. Фесенко Л. Лейбенко Л. Радченко Н. Курінько О. Голубка О. Онищенко popup.nrat_date 2020-04-02 Close