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Information × Registration Number 0214U003693, 0110U005317 , R & D reports Title New biochemical approaches for evaluation of metallic nanoparticles ecotoxicity based on determination of metallothioneins characteristics in water animals popup.stage_title Head Stoika Rostyslav, Registration Date 17-02-2014 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 A multimarker molecular analysis of the functional state of a bivalve mollusc Anodonta cygnea and a frog Rana ridibunda was implemented and the role of the metal-depositing proteins metallothioneins (MT) in the body response to the action of zinc oxide-containing nanomaterials and Zn salts in a water under physiologically relevant concentrations when given separately and in combinations with a thyocarbamate pesticide and a heat stress. It has been shown that the bivalve mollusc Anodonta cygnea, and lake frog Rana ridibunda represent the highly sensitive molecular targets for different molecular forms of zink. An elevation of methallothyonein protein content most likely due to activation of their expression under influence of Zn, nanoZnO and a nanoZnO+thyocarbamate. Methallothyonein system functions as an organic component of a stress response while correlating with an activation of antiooxidant defense. Under conditions of combined influence of nanomatherial and heat stress the hyperthermia appears to be a key component that modulates molecular responces to stress. Product Description popup.authors Корчинський Олександр Геннадійович Стойка Ростислав Стефанович Столяр Оксана Борисівна Фальфушинська Галина Іванівна popup.nrat_date 2020-04-02 Close