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Information × Registration Number 0214U006214, 0110U006130 , R & D reports Title Nanoconjugates of novel antitumor agents based on the specific ligands of quadruplex DNA - inhibitors of telomerase popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 19-02-2014 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 New ligands of quadruplex DNA (G4) based on phenazines and cyanines were obtained. Telomerase inhibitors active at micromolar concentrations were found. G4 structure and ligand interaction was studied. Methods of introducing the functional groups (SH, NHS) in some biocompatible polymers were developed. Polymers able to react with amino and SH derivatives were obtained. Methods to introduce reactive groups into inhibitors were proposed. TMP3 porphyrin conjugates with dextran and polymalic acid were prepared. TMP3 was non-covalently introduced in alginate hydrogel. These nanomaterials are able to release the attached inhibitor. Product Description popup.authors Ільченко Микола Миколайович Авдєєв Станіслав Сергійович Арешков Павло Олександрович Дубей Лариса Василівна Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close