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Information × Registration Number 0215U001713, 0111U008026 , R & D reports Title Remodeling blood channels of internal organs and tissues in various pathological conditions in the experiment popup.stage_title Head Herasymyuk Illya Yevhenovich, Registration Date 27-04-2015 Organization Ternopol State Medical University by I.Ya.Horbachevsky popup.description2 Objects of the research are structural features of the parenchyma and morphometric characteristics of the blood vessels of the internal organs and tissues reorganization in modeling of various pathological conditions. Purpose is to define the particular dynamic structural changes in the parenchyma and blood vessels of the internal organs and tissues in relation to changes in central hemodynamic. Morphological methods, injections, radiographic, morphometric and functional, mathematical, statistical methods are used in the research. Vessels branching in internal organs of rats are caused by specific features of the internal organs, remoteness from the aorta and vasomotor activity. Characteristic of vascular responses of internal organs depends on the type of circulatory disorders during simulation of pathological processes, accompanied by disturbances of the central hemodynamic. Blood vessels react depending on caliber: small arteries and arterioles (resistance vessels) react by constriction, larger caliber arteries - by increasing of the capacity due to dilation. The long-term effects of hypoxia on the background plasma and tissue permeation develop sclerotic nature processes that may be viewed as signs of decompensation. In such cases morphological changes that were developed in the early stages can not be reverse development. Restoration of central and organ blood flow after their previous disturbance at first is not accompanied by the restoration of the functional state. It leads to increasing of vascular responses and deepening of destruction during primary hemodynamic disorders. Gradual recovery of circulatory and structural organization of organs and tissues are observed at presence of sufficient compensatory opportunities in later periods of experiment. Application of developed and proposed experimental methods for correction of reperfusional changes allow to reduce the intensity of the syndrome non restoration of blood flow in the early postoperative period. Product Description popup.authors Боймиструк Ігор Іванович Гавліч Олег Богданович Гаврищук Юрій Миколойович Галицька-Хархаліс Олександра Ярославівна Гантімуров Антон Вячеславович Гданський Сергій Миколайович Гойдало Тетяна Русланівна Мізь Андрій Васильович Магдльона Віра Василівна Пилипко Іван Васильович Романюк Тетяна Іванівна Стравський Тарас Ярославович Федорович Олеся Андріївна Шкробот Леонід Володимирович Ющак Михайло Васильович popup.nrat_date 2020-04-02 Close