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Information × Registration Number 0215U008610, 0115U005409 , R & D reports Title Molecular biological effects and mechanisms of lactoferrin action on tumor cells in vitro and in vivo popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 30-12-2015 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Lactoferrin participation in the formation of the molecular and pro/antioxidant profile of breast cancer cells has been proven. It was found that substantial inhibition of lactoferrin expression observed in receptor negative breast cancer cells (MDA-MB-231, MDA-MB-468) is correlated with a reduction of adhesion and increase of invasive characteristics. Negative feed-back control of lactoferrin presence and indices of the pro/antioxidant cell defence of breast cancer cells (ROS level, "free iron", NO generation rate, lipid peroxidation and mitochondrial transmembrane potential) was found. Received data is a fundamental basis for the study of the mechanisms of exogenous lactoferrin modifying action on hormone-dependent and receptor -negative human breast cancer cells. Product Description popup.authors Борікун Тетяна Віторівна Бурлака Анатолій Павлович Бурлака Анатолій Павлович Задворний Тарас Володимирович Лук'янова Наталія Юріївна Тодор Ігор Миколайович Чехун Василь Федорович Яловенко Тетяна Миколаївна popup.nrat_date 2020-04-02 Close