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Information × Registration Number 0216U001486, 0115U005584 , R & D reports Title High-throughput screening and selection of сlass imidazole antimycotic and antitumor activity popup.stage_title Head Yemets Alla Ivanivna, Registration Date 16-02-2016 Organization Institute of Food Biotechnology and Cenomics of the National Academy of Sciences of Ukraine popup.description2 Identified anticancer imidazole compounds acting by a mechanism of tubulin inhibition. High-throughput virtual screening and molecular docking, identify that 21 from the 2886 compound are perspective for further in vitro testing. Influence of of selected compounds on tubulin-dependent GTP hydrolysis and dynamics of tubulin polymerization identify F1402-0153, B0152 and B0478-0477 as compounds with highest antimitotic and antitumor activity Product Description popup.authors Ємець Алла Іванівна Демчук Олег Миколайович Карпов Павло Андрійович Литвин Дмитро Іванович Ожерєдов Сергій Петрович Раєвський Олексій Володимирович Співак Світлана Ігорівна popup.nrat_date 2020-04-02 Close