Search academic texts

Information × Registration Number 0216U001519, 0113U000102 , R & D reports Title To study the mechanisms of immunocorrection using the combined application of hematopoietic stem cells and multipotent stromal cells popup.stage_title Head Nikolsky Igor Sergeevych, Registration Date 17-02-2016 Organization Institute of genetic and regenerative medicine Acad.Med.Sci. of Ukraine popup.description2 For the first time it was found the membrane affinity of MSCs and HSCs is of great significance and manifests in vitro the spontaneous formation of fibroblast-lymphocyte associations (fibroblast-lymphocyte rosettes, FLRs). The thymocytes possess the greatest ability to form FLRs. Their co-culturing with MSCs potentiates the induction of differentiation of these cells into osteogenic direction. It opens up the new ways to study the contact interaction between MSCs and HSCs in aspect of collagenoses pathogenesis. The HSCs and MSCs co-transplantation is significantly expressed more than individual cells alone. It helps to regenerate the immune system after the lesion caused by cyclophosphamide. Contact interaction of these cells in vitro also significantly changes their properties when transplanted into immunodeficient animals. It allows selecting the conditions for the directed creation of cell biologics with specific mechanism of regenerative effect. Product Description popup.authors Галицька С.М. Демченко Д.Л. Зубов Д.О. Нікольська В.В. Нікольський І.С. Семенова Я.-М.О. Тарануха Л.І. Трубецька Н.А. Федорчук О.Г. popup.nrat_date 2020-04-02 Close