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Information × Registration Number 0216U003071, 0110U000694 , R & D reports Title Molecular chaperon as a universal regulators of stress-indused signalling pathways cardiomyocytes popup.stage_title Head Sidorik L.L., Registration Date 12-01-2016 Organization Institute of Molecular Biology and Genetics popup.description2 The method immunobloting study conducted changed activation kaspase-3 and Bax in expression lick and subcellular fractions of hearts.That was the recorded an increase in the Bax protein in subcellular fraction , something characteristic of apoptosis. Investigated the location and level of Hsp60 in mitochondrial and cytosolic fractions of 2-and 3-month of mice hearts with induced myocardits and found growth Hsp60 protein in mitochondria and decrease it in the cytoplasm of cardiomyocytes with the development of disease. The results are similar to those that were shown earlier model DCM-like pathology. Although the level of Hsp60 reduced by 43%, but still remains higher than in the hearts of control mice, which correlates with smaller changes in miokardytnyh deheneratyvnymm hearts compared to dilated cardiomyopathy Product Description popup.authors І.В. Крупська Бобик В.І. Вігонтіна О.Г. Маркелова О.Ю. Рожко О.Т. Яковенко Л.Ф. popup.nrat_date 2020-04-02 Close