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Information × Registration Number 0216U003998, 0113U000101 , R & D reports Title Study the directed differentiation potential of multipotent mesenchymal stromal cells of different origin on the three-dimensional cultivation models popup.stage_title Head Gennadii M. Butenko, Registration Date 15-03-2016 Organization Institute of genetic and regenerative medicine Acad.Med.Sci. of Ukraine popup.description2 Protocols of adipose-derived stromal cells (ADSC) 3D-cultures were developed. We demonstrated that transplants of ADSC, which grouted in micromass culture and differentiated to osteogenic direction, can regenerate damaged bone tissue in mice. On the model of critical limb ischemia the improve perfusion and histomorphological characteristics of muscles after transplantation of hydrogels with ADSC was shown. The neuroprotective effect of bone marrow stromal cells in contact and non-contact co-culture with hippocampal tissue after oxygen-glucose deprivation was demonstrated. It is shown that syngeneic stereotactic transplantation of ADSC reduce degradation of myelin basic protein, inhibits gliosis and restore the corticospinal function in mice with periventricular leukomalacia. Product Description popup.authors Калмикова Олеся Олександрівна Кирик Віталій Михайлович Клименко Павло Павлович Кондратенко Костянтин Миколайович Луценко Тамара Миколаївна Нестеренко Дмитро Геннадійович Рибачук Оксана Андріївна Устименко Аліна Миколаївна Цупиков Олег Михайлович popup.nrat_date 2020-04-02 Close