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Information × Registration Number 0216U005548, 0113U000865 , R & D reports Title Genetic control of neurodegenerative diseases and muscular dystrophy in Drosophila melanogaster and study of mutagene activity of food flavours with use of pro-and eukaryotic test-systems popup.stage_title Head Chernyk Yaroslava Ivanivna, Bodnar Lidiia Stepanivna, Registration Date 03-02-2016 Organization Ivan Franko National University of Lviv popup.description2 Mutants by sws, Sod1 and Sod2 genes are characterized by intensification of lipid peroxidation and increased activity of SOD compared to wild-type; they have an increased sensitivity to prooxidants and reduced life span. It was found that penetrance of neurodegenerative phenotype in infected with Wolbachia, and non-infected mutant strains of swiss cheese group remained stable after treatment with tetracycline, while expressiveness significantly reduced in infected individuals. It was established that the gene-modifier Cam leads to a partial recovery of the mutant phenotype in dystrophy mutants. Flavor "Chocolate" ("Etol" company) in the studied doses in ana-telofase test in Allium cepa showed toxic effects and led to the emergence of various types of chromosomal aberrations. In Drosophila melanogaster it led to a doubling of the frequency of dominant lethal mutations compared to control. Mutagenic effects of the flavoring "Chocolate" ("Akras" company) was found only for increased doses in 10 times. The smallest mutagenic effect on two test systems was determined by the flavoring "Dark Chocolate" ("Givaudan" company). Product Description popup.authors Боднар Іванна Василівна Вітушинська Мар'яна Володимирівна Голуб Наталія Ярославівна Горбулінська Світлана Михайлівна Матійців Наталія Петрівна Могиляк Ірина Ігорівна Труш Олена Ігорівна Щербакова Оксана Василівна popup.nrat_date 2020-04-02 Close