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Information × Registration Number 0216U005573, 0115U003715 , R & D reports Title Alternative models for testing cellular agents on oncogenicity. The second year of implermentation. popup.stage_title Head Garmanchuk L.,Lukash K. Ivanov, Registration Date 03-02-2016 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2 Methodical approaches for separation and cultivation mesenchymal stem cells of placental origin of human and rats were developed. The evaluation of carcinogenic risks on organotypical models cultures of tumor cells was conducted on such parameters as the size and number of the formed spheroids, substrate-dependent growth of cultured cells under the influence of stem cells and produced them biologically active substances, adhesion and migration indicators, parameters of the cell cycle, pro- and antyapoptotic action, assessed phenotype of stem cells and target cells. On models with induced carcinogenesis and transplantable tumor growth in vivo the impact of stem cells on biological properties of tumors and primary cultures derived from tumors and blood for serum cytotoxicity was evaluated Product Description popup.authors popup.nrat_date 2020-04-02 Close