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Information × Registration Number 0216U006626, 0113U002274 , R & D reports Title Diagnosis and treatment of diseases of tissues and organs maxillofacial area popup.stage_title Head Grigorov Sergey Nikolaevich, Registration Date 14-04-2016 Organization 3.Kharkov national medical university popup.description2 Specified scientific data on the comparative analysis of the flow of mandibular fractures depending on the availability of antibiotics in the treatment regimen in young adults. The absence of statistically significant differences in outcomes in patients with the absence of antibiotics (96.00% of cases without complications in the group without the use of antibiotics against 96.67% in the group with systemic antibiotic therapy). It has been further developed to study the dynamics of biochemical parameters of patients with mandibular fractures in the study groups in the presence and in the absence of antibiotic therapy in the treatment regimen. It found no significant difference in terms of markers of bone remodeling. It has been established that patients who did not receive treatment with antibiotics, intermediates peroxidation level was on average 1.35 fold (p <0.05) lower than in patients receiving standard therapy using antibiotics. Refined scientific data on the dynamics of the immune status of patients with mandibular fractures in the study groups in the presence and in the absence of antibiotic therapy in the treatment regimen. It was found that patients treated with antibiotics, inhibits both phagocytic and humoral immunity. Patients treated with antibiotics infringements kislorodozavisimogo biocidal action mechanism of phagocytes. Indicators induced NBT test with patients, yaki not carried antibiotics, they averaged 48.16% against 22.33% in patients treated with antibiotics. It was found that patients treated with antibiotics, the level of cytokines was significantly lower compared with patients who received no treatment regimen antibiotic therapy. The oral fluid of patients treated with antibiotics, the level of secretory immunoglobulin A (sIgA) was lower in average of 1.4-fold (p <0.01), the lysozyme content was below an average of 1.6-fold (p < 0.01) compared with patients who did not use antibacterial agents. Advanced scientific concepts for comparative characteristics of oral microflora in patients with mandibular fractures in the study groups in the presence and in the absence of antibiotic therapy in the treatment regimen. This allows you to differentiate the indications for antibiotic therapy, namely not to prescribe antibiotics to patients hospitalized in the first two days after injury. Specified scientific data on the sensitivity of the microorganisms isolated from the oral cavity of patients with mandibular fractures, antibiotics and antiseptics. It was found that none of the drug had seized absolute activity against bacteria. The total percentage of susceptible and moderately resistant strains to the drug group bischetvertichnym ammonium compounds was 91.1. Product Description popup.authors Вакуленко Катерина Миколаївна Чирик Олександр Ігорович popup.nrat_date 2020-04-02 Close