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Information × Registration Number 0216U006634, 0113U002272 , R & D reports Title Chemical-pharmaceutical and experimental substantiation of nitrogen-соntaining organic compositions of pharmacological properties popup.stage_title Head Syrovaya Anna Olegovna, Registration Date 14-04-2016 Organization 3.Kharkov national medical university popup.description2 The quantum-chemical investigation of paracetamol and carbamazepine moleculas was conducted. Experimental study on comparative characteristics of analgetic, antiexudatic and antipyretic actions, antioxidant and oxidant activity of paracetamol, carbamazepin, caffeine and their compositions. Energy and electronic properties of paracetamol and carbamazepine molecules of by Quantitative Structure Activity Relationship (QSAR) method. Outcome analysis shows that caffeine has a potentiating effect on analgetic activity of paracetamol and carbamazepin, and antiexudatic and antipyretic action of paracetamol. It is expedient appointment of caffeine, paracetamol and their compositions relative to the horizontal motor activity, caffeine and its compositions with respect to grooming carbamazepine, paracetamol and caffeine - about the vertical motor activity. Ternary composition paracetamol + caffeine + carbamazepine effectively affect the state of lipid peroxidation and antioxidant activity in a formalin edema and can be recommended for further study. Product Description popup.authors Андрєєва Світлана Вікторівна Грабовецька Євгенія Романівна Козуб Світлана Миколаївна Краснікова Юлія Миколаївна Левашова Ольга Леонідівна Лук'янова Лариса Володимирівна Макаров Володимир Олександрович Петюніна Валентина Миколаївна Савельєва Олена Валеріївна Тішакова Тетяна Станіславівна popup.nrat_date 2020-04-02 Close