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Information × Registration Number 0217U001615, 0115U000808 , R & D reports Title Improve indications and treatment of patients with locally advanced and metastatic bladder cancer popup.stage_title Head Stakhovskyy Eduard Oleksandrovich, Registration Date 13-03-2017 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The object of study - 208 patients with locally advanced and metastatic bladder cancer. Purpose - to improve the medical and social rehabilitation and quality of life of patients with locally advanced and metastatic bladder cancer by improving the evidence and determine the effectiveness of surgical tactics in treatment. Methods: clinical, laboratory, radiation, statistics. Found that salvage cystectomy in patients with locally advanced and metastytychnym bladder cancer effectively eliminates symptoms like bleeding and degrades its quality (expressed dysuria, urinary incontinence and pain). The main requirements for salvage cystectomy and urinary derivation due to minor violations of homeostasis and life expectancy of patients is minimal invasiveness, ease of implementation and low number of postoperative complications. As a result, a randomized trial found that the widespread bladder cancer salvage cystectomy without lymphadenectomy is the operation of choice. This approach compared to the chemotherapy significantly improves the quality of life of patients due to decrease pain (70,1 ± 13,5) to (47,7 ± 17,0), respectively (p <0.05) increase in indicators of mental health patients (67,7 ± 17,8) to (50,2 ± 14,7), respectively (p <0.05), and does not affect its overall duration (p = 0.88). Proved that of orthotopic urine derivation (neoblader) in patients with locally advanced and metastatic bladder cancer after salvage cystectomy leads to a significant number of postoperative complications (60%), resulting from a violation of homeostasis, local and systemic progression, so given the small expectancy its performance life of patients is unnecessary and economically unjustified. Designed in the clinic a new method of skin urine derivation - modified ureterokutaneostomy is a simple, low-impact and highly effective method, while its implementation is (122 ± 21) minutes, does not require resection of the bowel, reducing the level of postoperative complications and 10%, and postoperative hospital stay to (6,6 ± 2,1), which meets all requirements salvage cystectomy in patients with locally advanced and metastatic bladder cancer is the best method of urinary diversion. Comparative analysis of external derivation urine (Briker) and modified ureterokutaneostomy showed high efficacy last, namely ease of implementation; reduce the number of postoperative complications early postoperative period 3.5 times (35% vs. 10% respectively) and reduce postoperative day bed to 3,2 (9,8 ± 1,8) to (6,6 ± 2,1), respectively (p <0.01). Determined that the execution salvage cystectomy is a preventive measure of life-threatening complications blader cancer locally, profuse bleeding, megaureter and chronic renal failure, the conditions for providing comprehensive treatment thereby improves median survival of patients up to 36 months to 21 at blader cancer (p <0,05). Results of research introduced at the National Cancer Institute, Odessa Regional Clinical Oncology Center, Lviv State Oncological Medical - Diagnostic Center. Product Description popup.authors Вітрук Юрій Васильович Войленко Олег Анатолійович Вукалович Петро Семенович Гаврилюк Оксана Миколаївна Катріченко Мирослава Олегівна Кононенко Олексій Анатолійович Лісний Іван Іванович Пікуль Максим Валентинович Стаховський Едуард Олександрович Стаховський Олександр Едуардович Чепурнатий Михайло Володимирович popup.nrat_date 2020-04-02 Close