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0217U001619,
0116U002404
,
Identify opportunities to improve high-dose chemotherapy with autologous stem cell transplantation in treatment of children with prognostically unfavorable solid malignancies
Klymniyk Grygoriy Ivanovich,
13-03-2017
Ukrainian Research Institute of Oncology and Radiology
Object of study: 160 children suffering from solid malignant tumors. The aim of this work is to improve the results improve the treatment of children with unfavorable prognostic solid malignant tumors by developing methods of early diagnosis, determination of risk groups, improvement of methods for high-dose chemotherapy with autologous stem-cell transplantation. Research methods – clinical, radiation, sonography, morphological, molecular genetic, and statistical. Equipment – gostepriimen Histos-5, Milestone, Italy, НМ325 microtome Thermo Scientific, Germany, instantaneous cytometer 7500 Real-Time PCR Systems "Applied Bіosystems", USA, ultrasound machine ATL HDI-5000 Philips USA. The result of research were investigated prognostic factors for these forms of solid malignant tumors (szn), as neuroblastoma and Ewing's sarcoma. To determine the prognostic factors applied in clinical, morphological, morphometric, immunohistochemical and molecular genetic methods, based on which the algorithm of early intensification of treatment of children suffering from a solid malignant neoplasms. The use of high-dose chemotherapy with autologous transplantation of stem cells of peripheral blood (VDHT with autotasks) has significantly improved survival in patients with neuroblastoma and Ewing's sarcoma. The total survival rate is respectively 42 % (neuroblastoma) and 32.5 % (Ewing's sarcoma) patients, while no – 10 % and 27.5 % of patients, respectively. The introduction of the technique of double (condemno) WIDHT with autotask statistically possible to increase bezretidivnuu the survival rate of children suffering from neuroblastoma high-risk groups of 8.3 %. Overall survival of patients who underwent only one element VDHT with autologous TSCPC is 51.8 per cent, recurrence of 38.5 %. Overall survival of patients who underwent double (tandem) WIDHT with autologous TSCPC is 63.2 %, recurrence – 46,8 %. The difference is statistically significant, p=0.02.
Іжовський Олексій Йожефович
Білоконь Олег Вікторович
Шайда Елен Вікторівна
2020-04-02
Updated: 2025-12-13
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