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Information × Registration Number 0217U001921, 0116U006002 , R & D reports Title Тhe study of pharmacological and toxicity IFT_000035 (cyclopenta [d] pyrimidine derivative), as a possible selective spasmolytic popup.stage_title Head Mochort Nikolay Antonovich; Demchenko Anatoly Mikhailovich, Registration Date 19-10-2017 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 Methodological approaches to the experimental modeling of hyperactive urinary bladder of rat's (mechanical, irritating, toxic) were practically fine-tuned. In vivo and in vitrо experiments are carried out on cyclophosphanic model of hyperactive urinary bladder for further comparison IFT_000035 on other models of pointed pathology. It was studied influence of IFT_000035 on the frequency of experimental animals' diuresis with cyclophosphanic model of hyperactive urinary bladder long-term experiment. It was investigated influence of IFT_000035 on the change of average volume of rats' urination in the setting of cyclophosphanic model of hyperactive urinary bladder in long-term experiment. IFT_000035 toxicity class was determined on intact rats (LD50>7.94 g/kg) Product Description popup.authors Бобкова Л. С. Геращенко І.В. Демченко С.А. Киричок Л.М. Мовчан О.Д. Хайрулін А.Р. popup.nrat_date 2020-04-02 Close