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Information × Registration Number 0217U002130, 0116U003350 , R & D reports Title Morphofunctional state of spleen and factors of immune reactivity in experimental carcinogenesis popup.stage_title Head Lisnychuk Natalia Yevgenivna, Кандидат біологічних наук Registration Date 20-01-2017 Organization Horbachevsky Ternopil State Medical Academy popup.description2 In induced carcinogenesis total toxic effect on erythrocyte membranes has been grown that is shown by likely increase of erythrocyte index of intoxication in experimental animals during all term of observation - 30 weeks. Due to cytoplasmatic membrane destruction and development of oncogenic endotoxity, it occurs release of toxic catabolites from local center in blood and generalization of pathological process. The chronic neoplastic endotoxity causes conformation of lipid membrane components, changes a functional capability of erythrocytes that inhibits their sorption activity. In experimental carcinogenesis there are significant disturbances that occur: increased manifestations of endotoxemia neoplastic syndrome , development of oxidative stress and functional Imbalances of enzyme and glutathione-dependent pathways of antioxidant protection that is connected with inhibition of mitochondrial respiratory chain by products of lipid peroxidation and activation of excessive ROS formation; the expressed accumulating of toxic products of llipid peroxidation in spleen tissue that negatively influences on morphofunctional state of studied organ. Product Description popup.authors Волков Костянтин Степанович Демків Ірина Ярославівна Калінічук Любов Олександрівна Небесна Зоя Михайлівна Олещук Олександра Михайлівна Чихира Ольга Володимирівна popup.nrat_date 2020-04-02 Close