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Information × Registration Number 0217U002901, 0116U005456 , R & D reports Title Study XAP UCKL-1 and MRPS18-2 expression, interacting with nuclear antigen of Epstein-Barr virus in samples of hepatocellular carcinoma as compared to normal liver tissue popup.stage_title Head Kashuba Elena Vitaliіvna, Доктор біологічних наук Registration Date 19-12-2017 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Levels of UCKL-1 protein expression were studied in 42 FSH-associated HCV-assays and in liver cells that detected the tumor. They also studied the expression of this protein in the lines of cells derived from FSH specimens and primary tumors using open databases. The expression of UCKL-1 protein was found to be higher in HCC cells and in liver cells surrounding the tumor than in liver samples of patients with cirrhosis. Moreover, the expression level of UCKL-1 protein was higher in cases of fecal relapse. Multivariate analysis of prognostic factors for fecal relapse has shown that the best prognostic factors for relapse are the level of expression of UCKL-1 in the tumor and microvascular invasion. It has also been shown that UCKL-1 protein is expressed at a higher level in all HCV cases, regardless of the presence of HCV. Expression of this protein increased with the progression of the disease on the fcc. By radioactive label and thin-layer chromatography, it has been shown that the UCKL-1 protein has enzymatic activity in the uridine mono-phosphorylation reaction. UCKL-1 protein activity as uracil-phospho-ribosyl transferase failed to show by means of oral methods. Product Description popup.authors Бреєва Ольга Володимирівна Бучинська Любов Георгіївна Глущенко Надія Миколаївна Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна Несіна Ірина Петрівна Юрченко Наталя Юріївна popup.nrat_date 2020-04-02 Close