Registration Number
0217U003015,
0114U003550
, R & D reports
Title
Pyrazole-containing bisphosphonates - promising substances of drugs for the treatment of bone tissue diseases.
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Head
Komisarenko S., Доктор біологічних наук
Registration Date
13-01-2017
Organization
A.V.Palladin Institute of Biochemistry of National Academy of Sciences
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It was conducted in silico design and screening of a number of patentable pyrazole containing bisphosphonates. The development and optimization of synthesis techniques as well as obtaining of several promising aminohydroxybisphosphonates (pyrazole-containing analogues) were carried out. It was demonstrated the ability of synthesized pyrazole-containing bisphosphonates to inhibit bone resorption and effectively enhance mineral metabolism in experimental nutritional osteoporosis. In vitro model systems synthesized bisphosphonates dose-dependently inhibited marker enzymes (alkaline phosphatase, pyrophosphatase), decreased cell viability and functional activity of monocyte/macrophage cell lines J774 A1 and RAW264.7 (osteoclast precursors).
Product Description
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Великий М.М.
Лісаковська О.О.
Лабудзинський Д.О.
Мазанова А.О.
Шиманський І.О.
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2020-04-02
