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Information × Registration Number 0217U003334, 0115U004325 , R & D reports Title Nature, regularities of synthesis of carotenoids pigments that determine biological activity of probiotic strains B. subtillis IMV B-7513 and B. amyloliquefaciens UKM B-5113 popup.stage_title Head Harhota Maxim Andreevich, Registration Date 30-03-2017 Organization Zabolotny Institute of Microbiology and Virology Ukrainian NAS popup.description2 It was established that the strains synthesize carotenoids, which located in a complex of lipids and carbohydrates. The pigments synthesis by strains began at the end of the exponential growth phase of cultures at periodic submerged cultivation. The maxsimal rate of carotenoids was determined in the middle of stationary phase and at the beginning of aging phase. Investigated strains characterized by probiotic features antagonist activity against opportunistic microorganisms, resistance to low pH and high concentrations of bile and bile acids, low adhesive and high enzymatic activity. Oral administrations of strains to test animals induced normalization of quantitative composition of intestinal microbiota in mice and birds, restoration of their organs microstructure, the accumulation of vitamin A in the liver, activation of cellular immunity5481 Product Description popup.authors Нечипуренко О.О. Хархота М.А. popup.nrat_date 2020-04-02 Close