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0217U004601,
0115U002946
,
Research of interactome and individual interaction of polypeptides elongation ribosomal system components with protein partner in human cancer cells
Negrutskii B.S, Доктор біологічних наук
20-02-2017
Institute of Molecular Biology and Genetics of NASU
Translation elongation factor complex eEF1H is a formation containing eEF1A elongation factor, which in the form of GTP binds aminoacyl-tRNA and brings it to the A site of the ribosome, and also due to hydrolysis of GTP provides stabilization correct codon-anticodon interaction on the ribosome. Factors Group 1B, is also part of the complex eEF1H, ensure alternative GDP spent on a new GTP molecule in eEF1A. Recently, we showed that both eEF1A, and eEF1B can be localized in the nucleus of human cells, which are known to be protein biosynthesis occurs. The function localized in the core components of the unit elongation of human cells remains unknown. In addition, recently it appeared the first data on the non-canonical, non-broadcast, complex functions eEF1B. The aim of our research is to reveal the non-canonical functions of complex components eEF1B. The aim of this project is the transcript of the interactome complex subunits eEF1H in the cytoplasmic and nuclear fractions of the cell.
Бондарчук Т.В.
Власенко Д.О
Капустян Л.М.
Лисецький І. Л.
Новосильна О.В
Порубльова Л.В
Шалак В.Ф.
2020-04-02
Updated: 2025-12-07
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