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Information × Registration Number 0217U006611, 0115U005799 , R & D reports Title The role of genetic polymorphisms in the pathogenesis of metabolic disorders in diabetes mellitus type II popup.stage_title Head Krishtal N.V., Registration Date 02-11-2017 Organization National Medical University by Bogomolets popup.description2 Purpose: To determine the pathogenetic role of the Pro12Ala polymorphism of the PPARG gene in the disturbance of lipid peroxidation and the antioxidant system in type 2 diabetes mellitus. Methods: biochemical, immuno-enzymatic and molecular-genetic (polymerase chain reaction in real time using Gene Amp® PCR System 7500, Applied Biosystems, USA) in 138 people, 88 of them are patients with type 2 diabetes and 50 are control group. The received results: the maximum intensification of lipid peroxidation develops in the first five years of the disease, the presence of the 12Pro allele of polymorphism rs1801282 of the PPARG gene is associated with an increased risk of the disease (OR=2.20). The presence of the ancestral genotype Pro12Pro is associated with a low level in the blood of insulin and catalase activity. In the first five years of the disease, the Pro12Pro genotype caused a large body weight, and as the duration of the disease increased, insulin level changes, insulin resistance index (HOMA-IR), diene conjugates, malonic dialdehyde and superoxide dismutase, catalase, and alfa-tocopherol. During the disease period of 5-10 years, Pro12Ala polymorphism predetermined an increase in the levels of diene conjugates, malonic dialdehyde and catalase activity Product Description popup.authors Грішов А.А. Зябліцев С.В. Кришталь М.В. Мироненко О.І. Мокрій В.Я. popup.nrat_date 2020-04-02 Close