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Information × Registration Number 0217U006670, 0117U007017 , R & D reports Title Investigation of synthetic transformations of 3-aryl (hetaryl) isocomarines and 4 aryl (hetaryl) -2,3-benzodiazepines - the way to the creation of new biologically active substances with an effect on the central nervous system. popup.stage_title Head Khilya Volodymyr, Registration Date 11-12-2017 Organization Taras Shevchenko Kiev University popup.description2 The object of the study is the processes of the recycling of the lactone fragment 3 (get) of aryl isocomarins under the action of nucleophiles as a way to create new heterocyclic compounds with biological activity. The purpose of the work is to identify the possibilities provided by 3 (g) aryl isocommars for the preparation of new heterocyclic derivatives with pharmacophoric fragments. Methods of research - organic synthesis, spectroscopy (NMR, IR, chromatography, mass spectrometry), processing and analysis of the results. An analysis of available information regarding the possibility of recycling isocomarines under the influence of N nucleophiles. A diverse set of 3 (hetero) aryl isocomarins is synthesized. A preliminary assessment of the ability to donor-acceptor interactions of a series of functionalized 3 arylisocoumarins and 3 aryl-3,4 dihydroaryli-isocumulins by recording their NMR spectra in the presence of LZR (Eu (fod) 3) was performed. New 4 aryl-2,3-benzodiazepine-1-them and their heteroanalogs based on 3 (alkyl / alkoxy / hydroxyphenyl) isocomarines and N-containing heteroanalogs of isocamarines were synthesized; The peculiarities of the formation of 3 (pyridine-2 (4) yl) -2,3-benzodiazepine-1 ones were studied. The range of 3 heterializo-cumarins synthesized on the basis of 3 (? bromoacetyl) isozyquamarine has considerably expanded; a series of new 3 hetaryl isoquinolones, 3 heteraryl-N methylisoquinolones and 3 heteraryl-1 chloroisoquinolines were obtained by their recycling.5481 Product Description popup.authors А.Р. Хайрулін В.В. Іщенко В.П. Хиля В.С. Москвіна Д.С. Мілохов Н.М. Богдан О.І. Тихонюк О.В. Шабликіна С.Л. Богза Т.С. Коваль popup.nrat_date 2020-04-02 Close