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Information × Registration Number 0217U006915, 0117U007021 , R & D reports Title Design, synthesis and mechanism of action of new antiepileptic/neuroactive compounds for multidirectional regulation of GABA and glutamatergic neurotransmission for the treatment of epilepsy and other neuropathology. popup.stage_title Head Borisova Tatiana Alexandrovna, Registration Date 27-12-2017 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The design and synthesis of a number of derivatives of 4-thiazolidinones as potentially neuroactive compounds was carried out. Leading compounds were selected for further studies of neuromodulatory effects on the rat brain nerve terminals. The compounds with opposite directional effect on the key characteristics of GABA- and glutamatergic neurotransmission were found. Product Description popup.authors Галкін М.О. Дударенко М.В. Камінський Д.В. Крисанова Н.В. Крищишин А.П. Лесик Р.Б. Лозинський А.В. Пастухов А.О. Позднякова Н.Г. popup.nrat_date 2020-04-02 Close