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Information × Registration Number 0218U000052, 0117U004314 , R & D reports Title The development of the program of comprehensive treatment of hemorrhagic complications in patients with hemophilia. popup.stage_title Head Yushchenko Petro Vasyliovych., Registration Date 16-01-2018 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of study. 15 patients with hemophilia and 10 healthy individuals. Research methods. Clinical, hematological, biochemical. It has been shown that anti-fibrinolytic drugs influence the pharmacokinetics parameters of drugs of factor VIII, namely, prolong the half-life and allow to maintain activity of factor VIII after 72 h at a level exceeding the target value of prophylactic treatment (2%) by 2.3 times. At the same time, the use of anti-fibrinolytic agents in complex hemostatic therapy regimens reduces prothrombin time, APTT and plasma recalcification time, hageman-dependent fibrinolysis in all observation periods,. It has been established that the use of corticosteroid hormones does not affect the pharmacokinetics and pharmacodynamics of factor VIII drugs. In the use of drugs of factor VIII there is a decrease in the level of median-molecular peptides during the first day after administration of the drug 1.8 and 1.7 times (p <0.001) in the fraction of MSM D254 and 1.7 times in D280 (p <0.001) and restore it level in subsequent monitoring periods. Medicine. Product Description popup.authors Авер'янов Євгеній Валентинович Аношина Мілітіна Юріївна Асса Олексій Валерійович Бурнаєва Світлана Валентинівна Семеняка Володимир Іванович Ющенко Петро Васильович Яговдик Марина Всеволодівна popup.nrat_date 2020-04-02 Close