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Information × Registration Number 0218U001151, 0117U000021 , R & D reports Title Obtaining of biologically active compounds and monomers based on the principles of supramolecular catalysis and "green" chemistry popup.stage_title Head Popov Anatoliy Fedorovich, Доктор хімічних наук Registration Date 24-01-2018 Organization LM.Litvinenko Institute of Physical Organic and Coal Chemistry popup.description2 As a result of the performed research, a general approach to the synthesis of 1,2-diazepines based on the interaction of N-aminoheterocycles with carbonyl compounds in an acidic medium is proposed. The synthetic limits of these reactions have been investigated using a wide range of carbonyl compounds and optimal conditions for cyclization with different classes of carbonyl compounds have been selected, allowing for a wide variety of substituents. A general way of constructing 2- (1-hetero-3-ylmethyl) -1H-benzimidazoles is proposed by condensation of the corresponding heparic acid acids from o-phenylenediamine in a polyphosphoric ester medium. 2- (1-Hetero-3-ylmethyl) -1H-benzimidazole-1-amines are obtained by reacting the electrophilic amination of 2- (1-hetero-3-ylmethyl) -1H-benzimidazoles with hydroxylamine-o-sulfonic acid (HACC). Methods of obtaining benzothienodiazepines, benzofuridiazepines condensed with the benzimidazole fragment, cyclization of the corresponding derivatives of parabens of 2- (1-hetero-3-ylmethyl) -1H-benzimidazole-1-amines with Pict-Spengler reaction were developed. New condensed diazepines are synthesized, which can be used to create new drugs. Product Description popup.authors Білобров Володимир Михайлович Богза Сергій Леонідович Гресько Сергій Володимирович Ніколаєв Олексій Сергійович Раєнко Генадій Федорович Смирнова Ольга Володимирівна Суйков Сергій Юрійович Толкунов Андрій Сергійович Толкунов Валерій Сергійович Толкунов Сергій Володимирович Хижан Олександр Іванович popup.nrat_date 2020-04-02 Close