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Information × Registration Number 0218U001388, 0116U007817 , R & D reports Title Receptor-mediated signaling pathways in pathobiology of chronic lymphocytic leukemia malignant cells popup.stage_title Head Sidorenko Svitlana Pavlivna, Registration Date 07-02-2018 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was established that a separate ligation of CD150 or CD180 leads to the activation of Akt and MAPK signaling pathways in malignant transformed B lymphocytes of CLL. Сombined activation of these receptors results in the blocking of the phosphorylation of the Akt kinase and its targets-mTOR, 70S6K, S6RP and 4E-BP, complete inhibition of the phosphorylation of p38MAPK kinase. Analysis of the expression profile of transcription factors in CLL has shown that malignant transformed B lymphocytes are characterized by reduced expression of PU.1 and an elevated level of SPIB. Product Description popup.authors Гордієнко Інна Михайлівна Ковалевська Лариса Миколаївна Сидоренко Світлана Павлівна Холоднюк Валерія Михайлівна Шлапацька Лариса Миколаївна popup.nrat_date 2020-04-02 Close