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Information × Registration Number 0218U001553, 0116U002404 , R & D reports Title Identify opportunities to improve high-dose chemotherapy with autologous stem cell transplantation in treatment of children with prognostically unfavorable solid malignancies popup.stage_title Head Klymniyk Grygoriy Ivanovich, Registration Date 22-02-2018 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Object of research: 160 children, patients with solid malignant neoplasms. The aim of the work is to improve the results of treatment of children with prognostically unfavorable solid malignant neoplasms by developing an early diagnostic methodology, identifying risk groups, and improving the methodology for high-dose chemotherapy with transplantation of autologous stem cells. Methods of research - clinical, radiation, sonographic, morphological, molecular genetic, statistical. Equipment - histo-processor Histos-5, Milestone, Italy, HM325 Thermo Scientific, Germany, flow cytometre 7500 Real-Time PCR Systems "Applied Bio Systems", USA, ATL HDI-5000 Philips US device. As a result of the research carried out, the existing schemes of high-dose polychemotherapy with autologous transplantation of peripheral blood stem cells (IVCT with autotocular tuberculosis) in the treatment of solid malignant neoplasms (SCN) in children (CJ, neuroblastoma, brain tumors, teratoblastoma) were optimized, the optimal term and combinations modes of double (tandem) VDHT with autotocell with neuroblastoma and tumors of the brain. The use of VDHT with autotocular tuberculosis has greatly improved the survival rate of patients with neuroblastoma and Ewing's sarcoma. Overall survival rate is 42% (neuroblastoma) and 42.5% (Yinginga sarcoma) respectively, whereas without-10% and 27.5% of patients respectively. The introduction of the method of double (tandem) VDHT with autostocking has statistically significantly increased the non-recurrent survival rate of children with high risk neuroblast group by 8.3%. The overall survival rate of patients, which was performed only one element of VDHT with autologous TSCPC, is 51.8%, non-recurrent - 38.5%. The overall survival rate of patients undergoing dual (tandem) IVCT with autologous TSCC was 63.2%, non-recurring - 46.8% (p = 0.02). Product Description popup.authors Іжовський Олексій Йожефович Велимчаниця М. Шайда Елен Вікторівна popup.nrat_date 2020-04-02 Close