Registration Number
0218U002000,
0115U002945
, R & D reports
Title
Target-specific search of aminoacyl-tRNA synthetases inhibitors with selective action against agents cause human infections diseases.
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Head
Tukalo Mykhaylo, Доктор біологічних наук
Registration Date
02-01-2018
Organization
Institute of Molecular Biology and Genetics of NASU
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Homology models of seryl-tRNA synthetase from Staphylococcus aureus have been built using three web-servers - Swiss-Model, Phyre2, I-TASSER and the program Modeller9.17. The structural features of these models have been investigated. The models have been superimposed on the human cytoplasmic seryl-tRNA synthetase. Obtained homology models have been evaluated using web-server MolProbity. Accordingly to the MolProbity data, the homology models which were generated with Swiss-Model server based on the crystal structures of seryl-tRNA synthetase from Aquifex aeolicus VF5 (PDB ID: 2DQ3) and human cytoplasmic seryl-tRNA synthetase (PDB ID: 4RQE), have demonstrated the best quality. The last one was taken for comparison of its tRNA- and aminoacyl-adenylate binding sites with human enzyme. Several structural features have been identified which should be taken into account during development of inhibitors with selective action toward bacterial seryl-tRNA synthetase
Product Description
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Бджола Володимир Григорович
Волинець Галина Петрівна
Гудзера Ольга Йосипівна
Дудченко Тарас Миколайович
Кpикливий Iван Андрійович
Коваленко Оксана Петрівна
Лукашов Сергій Степанович
Раєвський Олексій Володимирович
Рибак Марія Юріївна
Яpемчук Ганна Дмитрівна
Ярмолюк Сергій Миколайович
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2020-04-02
