Search academic texts

Information × Registration Number 0218U003367, 0115U000808 , R & D reports Title Improve indications and treatment of patients with locally advanced and metastatic bladder cancer popup.stage_title Head Stakhovskyy Eduard Oleksandrovich, Registration Date 02-02-2018 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The subject of the study - 247 patients with locally advanced (T4) and metastatic urinary bladder cancer (N1-3 or M1). The purpose of the work is to increase the level of medical and social rehabilitation and quality of life of patients with locally-distributed and metastatic bladder cancer by improving the indications and determining the effectiveness of surgical tactics in integrated treatment. It is revealed that the main pathomorphological features that determine the high aggressiveness of tumors and lead to the development of local and metastatic PCM are a significant proportion of low and undifferentiated forms of transition of cellular cancer (57.9%) and a high percentage of squamous cellular (36.8%) and glandular metaplasia (6.1%). As a result of a randomized trial, it has been found that cysticectomy without lymphadenectomy with distributed PCM is a choice operation. This approach compared with PCT significantly improves the quality of life of patients by reducing the symptoms of pain and overall patient health and increasing the mental health of patients, but does not affect its overall duration (p = p = 0.71). The comparative analysis of external urine derivation according to Brickker and modified Ureterocutaneostomy showed the high efficiency of the latter, namely: ease of implementation, reduction of the number of postoperative complications of the early postoperative period by 2.3 times and reduction of the postoperative bed of the day by 2.7 (p <0.01). Ureterocutaneostomy is a simple, less traumatic and highly effective method developed at the clinic: its time of making (187 ± 73) minutes, does not require resection of the intestine, which reduces the level of postoperative complications to 11.7%. It has been proved that the use of multimodal analgesia based on dexketoprofen and paracetamol with the epidural block and early onset of parenteral nutrition during cystectomy contribute to adequate anesthesia, stable hemodynamics, postoperative complications reduction, early restoration of the native state, and reduction of the duration of treatment for patients with locally advanced and metastatic RSM Product Description popup.authors Вітрук Юрій Васильович Войленко Олег Анатолійович Вукалович Петро Семенович Гаврилюк Оксана Миколаївна Закальська Х. Кононенко Олексій Анатолійович Лісний Іван Іванович Оніщенко А. Пікуль Максим Валентинович Стаховський Едуард Олександрович Стаховський Олександр Едуардович Чепурнатий Михайло Володимирович popup.nrat_date 2020-04-02 Close