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Information × Registration Number 0218U006624, 0115U001048 , R & D reports Title To explore the gender features of "family" multiple sclerosis and to develop the approaches for determining the risk of demyelinating disease in successive-burdened offspring with multiple sclerosis (experimental study) popup.stage_title Head Berchenko Olga, Registration Date 02-07-2018 Organization Ukrainian SRI of Clinical and Experimental Neurology and Psychiatry popup.description2 The subject of the study were 960 laboratory rats (510 females, 450 males) and 190 patients with different types of multiple sclerosis (142 women, 48 men). The purpose of the work was to study the sex and age characteristics of experimental autoimmune encephalomyelitis (EAE) as a model of "sporadic" and "family" forms of multiple sclerosis (MS) in ani-mals, taking into account the type of hereditary aggravation. Methods of the study were clinico-ethological, epidemiological, physiological, immunological, bio-chemical, population, genealogical, statistical. A list of measuring instruments is given in Supplement A. On the basis of EAE induction as a model of MS, the influence of heredity on the predisposition to the development of autoimmune demyelinating pathology was studied depending on sex, age and type of burden of offspring. It is shown that in the mechanisms of its realization in females, the priority value be-longs to the environmental component, in contrast to males with predominance of the genetic constituent. It has been established that the incidence of females does not depend on the age and family anamnesis; along with sexually mature males, which are characterized by the greatest susceptibility to induction of the EAE in the male strain. Antenatal stress contributes to increased sensitivity to induction of EAE in sexually mature males and females in the pubertal period of ontogenesis. In the pre-pubertal age, regard-less of gender, the incidence rate is reduced (by a factor of 2) due to the level of functional activity of the hypothalamic-pituitary-adrenal axis of the endocrine system, whose effect in sexually mature rats is modulatory (compensatory), but not pathogenetic in origin as in the onset of experimental MS, and in the formation of remission. The role of gender, age, conditions of antenatal development, the level of func-tional activity of the system of steroid hormone synthesis, the type and degree of hereditary complication as risk factors for the development of demyelinating pathology in hereditarily burdened offspring was determined in the conditions of modeling the "family" forms of experimental MS. Product Description popup.authors Єна Р. А. Гейко В. В. Кириченко О. В. Лекомцева Є. В. popup.nrat_date 2020-04-02 Close