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Information × Registration Number 0219U000005, 0117U001729 , R & D reports Title Experimantal estimation of the effectiveness of application and biocompatibility testing algorithm of domestic implantation materials, based on calcium phosphates, for the restoration of the function of the musculoskeletal system in the malignant process popup.stage_title Head Lukianova Nataliia Yuriivna, Registration Date 03-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The study of biomin effects of on receptor status and apoptosis indices in normal fibroblasts, human breast and prostate cancer cells with different sensitivity to hormonal therapy has been conducted. We had established an increase in the level of expression of oncogenic miR-221 under the influence of biomin in hormone-sensitive breast and prostate cancer cells, which contributes to a slight reduction of steroid hormone receptors: in MCF-7 cell line the estrogen ? and progesterone receptors at 1.23 and 1.19 times, respectively; in the line of LNCaP - androgen receptors, estrogen, estrogen , progesterone and HER2 / neu - at 1.32, 2, 1.5, 3.7 and 2.84 times, respectively. It was found that under the influence of there is a decrease in the expression level of oncosuppressive mRNA-320a biomin in the hormone-resistant breast and prostate cancer cells. These changes are accompanied by a alteration in the level of apoptosis-regulating protein - an increase of p53 and Bcl-2 the expression, as well as a decrease of Bax expression in MDA-MB-231 and DU-145 cells at 26%, 12% and 59% and 60%, 16% and 33% respectively. It was shown that cultivation of hormone-resistant breasr and prostate cell lines with biomin also causes an increase of the ROS generation in 2.77 and 2.73 times. It has been determined that biomin does not affect the parameters of receptor status and apoptosis in normal fibroblast cells. Product Description popup.authors Безденежних Наталя Олександрівна Борікун Тетяна Вікторівна Горбик Дарья Миколаївна Задворний Тарас Володимирович Коноваленко Володимир Федорович Кунська Любов Миколаївна Лихова Олександра Олександрівна Лук'янова Наталія Юріївна Трембач Людмила Валентинівна Чехун Василь Федорович Яловенко Тетяна Миколаївна popup.nrat_date 2020-04-02 Close