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Information × Registration Number 0219U000846, 0117U002034 , R & D reports Title Molecular and biological factors of malignant cells heterogeneity and variability of clinical course of hormone dependent tumors popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 01-03-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 For the first time, it was established that the differences in proliferative potential of sensitive and resistant cells are due to the changes in the metabolism of polyamines required for maintaining the activity of the transcription factor NF-kB, and the shift in homeostasis of the essential elements (copper, zinc, iron, magnesium) involved in the formation of pro / antioxidant balance. It has been proven that the acquisition of a resistant phenotype by sensitive cells leads to pronounced changes in individual links of energy metabolism and the distribution throughout the phases of cell cycle. In particular, the formation of a resistant phenotype is accompanied by an increase in the level of insulin expression against the background of a significant decrease in glucose uptake. At the same time, incubation of MCF-7/Dox cells but not sensitive MCF-7 cells with insulin redistributed cells from S phase to G2/M phase of cell cycle. Obesity, diabetes, and arterial hypertension in breast cancer patients have been found to be associated with a significant increase in the level of adipose tissue hormone leptin and a decrease in adiponectin level in peripheral blood serum. This leads to an increase in cytochrome P-450 activity, the accumulation of genotoxic metabolites of steroid hormones and the creation of a specific tumor microenvironment characterized by increased levels of superoxide radicals, the damage to NO synthase and, as a result, a decrease in NO, high gelatinase activity and low adiponectin content. The obtained results open up a new layer of knowledge about the pathogenetic mechanisms of the formation of the metabolic syndrome as an endocrine-genotoxic factor modulating the biology of hormone-dependent tumors that allows one to determine a number of informative biomarkers for early diagnosis and prognosis of the most prevalent hormone-dependent tumors in female and male patients. Product Description popup.authors Бучинська Л.Г. Ганусевич І.І. Діденко Г.В. Завелевич М.П. Залєток С.П. Ковалевська Л.М. Лихова О.О. Лозовська Ю.В. Лук'янова Н.Ю. Маковецька Л.І. П'ятчаніна Т.В. Сарнацька В.В. Соляник Г.І. Тодор І.М. Чехун В.Ф. popup.nrat_date 2020-04-02 Close