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Information × Registration Number 0219U000895, 0118U004142 , R & D reports Title Investigation of the possibility of potential drugs enantiomers obtaining using Rapana venosa carboxylesterase popup.stage_title Head Shesterenko Yevgeniia Arkadiyivna, Registration Date 13-03-2019 Organization A.V. Bogatsky, Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 Homogenates of the esophageal gland and hepatopancreas of Rapana venosa have been obtained. It was found, that esterase activity of the obtained homogenates, determined for 2-naphthyl acetate was higher, than for 1-naphthyl acetate. The belonging of esterases in homogenates of Rapana venosa to the carboxylesterase family was confirmed. Greater activity of the esophageal gland homogenate esterases in the acidic medium and at high temperatures was shown. Using Rapana venosa digestive glands homogenates enantioselective hydrolysis of 3-acetoxy-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one was performed. The preferential formation of R-enantiomer was shown (enantiomeric excess of R- enantiomer was 42 %). Product Description popup.authors Шестеренко Євгенія Аркадіївна popup.nrat_date 2020-04-02 Close