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0219U000967,
0118U003729
,
To develop and improve methods of personified treatment of patients with serous ovarian cancer
Svintsystkiy V.,
21-03-2019
Ukrainian Research Institute of Oncology and Radiology
The object of the study is 54 patients with serous ovarian cancer. The purpose of the work is to optimize treatment of serous ovarian cancer by developing and improving personified approaches. Research methods and equipment: clinical, clinical-laboratory, radiological, morphological, immunohistochemical, ultrasonic, radioisotope, genetic, statistical; Nano Drop 1000 (Thermo Fisher Scientific, USA) and 7500 Real-Time PCR Systems (Applied Bio Systems, USA) spectroscopy. The frequency of hereditary BRCA1 mutations (5382insC, 185delAG, 4153delA, 300T> G, 2080delA) and BRCA2 6174delT among 424 patients with serous ovarian cancer in Ukraine. It was found that most of the mutations in BRCA1 5382insC are recorded in Ukraine - 67%, 300 T> G - 18%, 4153delA - 9%, 185delAG - 4%, 2080delA - 2%. Personified methods for the treatment of patients with serous ovarian cancer based on BRCA status have been developed (HIPEC has been conducted in 12 patients, PCI-17). A set of material was developed for improving the impressions for neoadjuvant chemotherapy and interval cytodenection in patients with serous ovarian cancer by laparoscopic staging (16 surgical interventions). The protocol of intensive therapy during cytereductive surgical interventions is optimized; The analysis of 117 histories of diseases and outpatient cards of patients with serous ovarian cancer treated by standard methods from 2009 to 2017 in NIR (most often relapses were diagnosed in 2 years -37.9%; localization of relapses: small pelvis - 13 (44.8 %), peritoneum - 11 (37.9%)
Лигирда Наталія Федорівна
М.Єгоров
Неспрядько Сергій Валерійович
Свінціцький Валентин Станіславович
Ціп Наталія Павлівна
2020-04-02
Updated: 2025-12-13
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