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Information × Registration Number 0219U001736, 0118U003769 , R & D reports Title To investigate the role of the allelic polymorphism of the glutathione-S-transferase genes of the classes P1 (GSTR1), T1 (GSTT1) and M1 (GSTM1) and other factors in the development of bronchoobstructive disorders in children living with radioactive contaminated territories popup.stage_title Head Stepanova Yevgeniya Ivanovna., Доктор медичних наук Registration Date 25-02-2019 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of research: children - inhabitants of radioactive contaminated territories (RZT) with chronic pathology of bronchi and lungs and without pathology of bronchi and lungs. Purpose: To determine the functional state of the bronchopulmonary system based on a comprehensive clinical, laboratory, and environmental risk factors and the activity of the pro- and antioxidant system in children living in radioactive contaminated areas. Methods of research: clinical, laboratory, biochemical, instrumental, statistical. Results and their novelty. It is determined that the formation of chronic bronchopulmonary pathology is influenced by a complex complex of factors, the leading ones being burdened heredity, unfavorable microsocial environment, numerical medical and biological factors of risk in the mother, some pathological conditions of the child in the infant period, certain features of early childhood, as well as dose maternal thyroid gland load, total parental exposure and 137Cs incorporated into the child's body. The study of lung ventilation showed that children with RBD with chronic bronchial and lung pathology reduced respiratory passivity at different levels of the bronchial tree and a high incidence of bronchial hyperreactivity. In children - RZT patients who did not have broncho-pulmonary pathology, there was a high frequency of bronchial hyperreactivity. Determination of the pro-and antioxidant system status showed a decrease in the activity of antioxidant enzymes in RZD children, both with and without chronic bronchial and lung pathology. In children with chronic bronchopulmonary pathology, elevated levels of TBC-active products of poly (malonic dialdehyde) in serum have been detected. The index of the main enzyme of the detoxification system of xenobiotics - glutathione transferees in children - residents of RZT without pathology of bronchi and lungs was higher than the similar indicator in children with chronic bronchopulmonary pathology. Investigation of the correlation between the parameters of the functional state of the respiratory system, the pro- and antioxidant system in children-residents of RZT has determined that the bronchial permeability at different levels of the bronchial tree is inversely correlated with the content of the blood products of the LPO and is directly correlated with the activity of antioxidant enzymes and glutathione transferase. The activity of glutathione transferees is inversely correlated with the frequency of bronchial hyperreactivity. The correlation between the pro-antioxidant system indices in RST children was characterized by inverse relationship correlations of serum MDA content with the activity of antioxidant enzymes and glutathione transferees. The inverse correlation of 137Cs content in the body with glutathione transferase activity is determined. Product Description popup.authors Альохіна Світлана Михайлівна Вдовенко Віталій Юрійович Зигало Віктор Миколайович Колпаков Ігор Евгенович Познищ Вікторія Анатоліївна popup.nrat_date 2020-04-02 Close