Search academic texts

Information × Registration Number 0219U001860, 0116U001209 , R & D reports Title Development of methods of synthesis of novel chemotypes of drug-like nitrogen containing heterocyclic compounds popup.stage_title Head Сhebanov Valentin Anatolievich, Registration Date 18-03-2019 Organization State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine popup.description2 Selective methods for the synthesis of spiropyrrolidine-3,2'-oxindoles by 1,3-dipolar cycloaddition reactions have been developed, their chemical properties have been studied; the reactions of heterocyclization of nitrogen-containing 1,3-binucleophiles and methylene-active compounds to obtain new types of non-planar heterocyclic systems were investigated; there were obtained peptidomimetics in isocyanide multicomponent reactions, 3-amino-5-methylisoxazole was first used in the Ugi reaction; novel heterocyclic systems based on cyclic triterpenoids of the lupane series with potential antitumor activity, containing substituted 1,2,3-triazoles, connected via an ether linker, were synthesized; the efficiency of nucleophilic heteroaromatic substitution was shown in the presence of acid to use aromatic and aliphatic amines as nucleophiles at high temperatures using microwave heating; the possibilities for the synthesis of heterocyclic systems of the 2-pyridone and benzo[4,5]imidazo[1,2-a]pyridine series by the "green chemistry" methodology have been expanded. Various types of biological activity for the obtained compounds were studied. Techniques for intensifying of chemical processes using ultrasound have been developed, methods for synthesizing nitrogen-containing supramolecular containers have been scaled, the use of microwave heating to destroy organic compounds has been studied, with a significant decrease in spectral interferences caused by the imposition of emission signals from polyatomic particles on the analyte line. Product Description popup.authors Бєліков К.М. Брильова К.Ю. Гладков Є.С. Горобець М.Ю. Десенко С.М. Збруєв О.І. Комихов С.О. Ліпсон В.В. Лузанов А.В. Мурликіна М.В. Мусатов В.І. Пінчукова Н.О. Павловська Т.Л. Сараєв В.Є. Сахно Я.І. Семененко О.М. Софронов Д.С. Чебанов В.А. Широбокова М.Г. Щербаков І.Б.-Х. popup.nrat_date 2020-04-02 Close