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0219U003197,
0118U001128
,
Peptides with photo-directed biological activity - inhibitors of intracellular processes involved in the development of cancer diseases.
Komarov Igor,
28-01-2019
Taras Shevchenko Kiev University
Object of research: the design and synthesis of amino acids, which are photosensitive, fluorescent, conformationally limited and / or contain fluorine-containing substituents; the introduction of synthesized amino acids into the composition of known biologically active peptides by solid phase peptide synthesis; studying the biological properties of peptides (peptidomimetiki) obtained and their pharmacological characteristics for the purpose of their use in the diagnosis and treatment of infectious diseases and cancer diseases. Methods of research: organic synthesis, computer simulation, analysis by means of physical methods. The design and synthesis of new fluorine-containing, fluorescent and photosensitive amino acids was carried out. New synthesized fluorine-containing amino acids (analogues of natural amino acids - valine, leucine, isoleucine, methionine, arginine and lysine) meet all the requirements of compounds that can be used as labels for 19F-NMR spectroscopy - have a rigid hydrocarbon skeleton monofluoro substituted in an optically active form, Fmoc-protected for use in solid-phase peptide synthesis. The fluorescent amino acid was designed on the basis of a heterocyclic nucleus - 2-hydroxychromone, and exhibits two-band fluorescence. New photosensitive amino acids were synthesized based on spirocyclical photoconductors. The synthesized fluorine-containing amino acids have been introduced into known peptides to validate their use as labels for spectroscopic studies and diagnostics. Employees of the NSC "Institute of Biology" of the KNU have developed methods for the biological research of photosensitive peptides on cultures of cancer cells adapted to the research tasks, namely, the study of dimming and low concentrations of biologically active substances. Methods have been used to study synthesized photosensitive antibiotics and on the basis of these studies developed recommendations for the use of antibiotics in the treatment of malignant formations.5481
Комаров І.В.
Радченко Д.С.
2020-04-02
Updated: 2025-12-07
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