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Registration Number

0219U003402, 0116U002527 , R & D reports

Title

Mechanisms of regulation of metabolic processes in the body under conditions of pathological conditions

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Head

Ostapchenko L.,

Registration Date

11-02-2019

Organization

Taras Shevchenko Kiev University

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On the basis of developed and adapted models of pathologies associated with disorders of metabolic processes (obesity, diabetes, metabolic syndrome, ischemic stroke, chemical burns of the esophagus), regulatory mechanisms were investigated, the development of these pathologies involved, and the effects of metabolic dysfunctioning. The data obtained during the study indicate significant impairment in the functioning of the coagulation, fibrinolytic and vascular-platelet sections of the hemostasis system and demonstrate the effector properties of the proteins and peptide pool accumulated in the body for the atherothrombotic and cardiomyological subtypes of ischemic stroke and are capable of exerting regulatory influence on individual metabolic units substances It is revealed that the development of the pathological process for ischemic stroke, burn disease, obesity is associated with a violation of the proteolytic balance, which is manifested in the redistribution of proteolytic enzymes between tissues, the violation of activator-inhibitor homeostasis and the activation of proteolytic reactions. The obtained results justify the contribution of proteolytic protein degradation as a potent trigger of metabolic dysfunction. It was shown that the development of obesity is accompanied by changes in the microbiota of the colon, the activation of the immune response for the Th2 type in female animals, and for the Th1 type - in male animals, a violation of neuromuscular transmission and a violation of the functional state of muscle cells. BRCA1 5382insC-mutation was identified in 1892 among ovarian cancer patients in Ukraine and no BRCA2 6174delT mutations were detected. Instead, a new, previously unknown mutation 6172delAG, which is also functionally a mutation of the reading frame shift and negatively swings to the function of the corresponding protein, was discovered. Kissceptin has been shown to activate neurocytes and astrocytes of the arcuate and preoptic nuclei of the hypothalamus of 3-month rats, whereas the KP receptor blocker does not inhibit the morphofunctional state of neurocytes of 3-month-old animals. It was discovered that the dopaminergic system of the brain may be involved with the involvement of D1 receptors of dopamine to the realization of stimulating effects of melatonin on the central structures of the hypothalamic-thyroid complex in the evening, and on the thyroid gland itself at night. Comprehensive study of the biological effects of Trigonella foenum graecum L. powder, Phaseolus vulgaris extract and melanin from yeast-like fungus Nadsoniella nigra (strain X1) substantiates the promise of their use for the development of biotechnological products for prophylactic and therapeutic action for the correction of pathologies development. Data obtained in the study of potential mechanisms underlying the development of various pathological conditions show the possibility of developing diagnostic algorithms, test systems and prognostic manipulations, to improve the diagnosis and correction of metabolic disorders of the functioning of the organism.

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Є.Тукалєнко
І.Зима
В.Верещака
В.Конопельнюк
В.Сорока
В.Шепелевич
Д.Ноздренко
К.Кременецька
М. Тимошенко
Н.Нурищенко
Н.Філімонова
П.Янчук
С.Весельський
Т. Коваль
Т.Вовк
Т.Галенова
Т.Довбинчук
Т.Червінська
Ю.Бабенюк
Я. Раєцька

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2020-04-02