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Information × Registration Number 0219U003591, 0116U003571 , R & D reports Title Study of structure and functional changes in thyroid gland in patients wiht benign and malignant tumors of the breast, which suffered from assident on CAES. popup.stage_title Head Lytvynenko Alexsandr Alexsandrovich, Registration Date 29-01-2019 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of research: structural and functional changes in thyroid gland (thyroid gland) in patients with benign and malignant neoplasms of the mammary glands (MH) who suffered as a result of the accident at the ChNPP (129 people). The purpose of the work is to examine the nature of structural and functional changes in the thyroid gland in patients with benign and malignant tumors of the mammary gland, taking into account the parameters of estradiol, progesterone and prolactin, who suffered from the Chernobyl accident. Methods of research: general-clinical, radiological, ultrasonographic, biochemical, morphological, immunohistochemical, statistical. Results and their novelty. Structural changes in the thyroid gland in patients suffering from the Chernobyl catastrophe and living in contaminated areas with benign nodal neoplasms in the MR were found in 63.26%, in patients with breast cancer (CM) - 75%, changes indicators of functional thyroid function in patients with benign tumors - in 40,81%, patients with breast cancer - in 27,5%. The increased level of markers of the reproductive panel in patients with benign MH was found at 32.65%, with malignant neoplasms of MH - at 18.75%. The estrogen receptors are found in 48.97% of patients with benign neoplasms. The estrogen receptors in the breast cancer tissue were detected in 73.75%, progesterone - in 60% of patients. The index of activity of cell proliferation in benign neoplasms at the level of 1-5% was in 71.42% of patients, at 10-30% - at 21.42% and at 40% - in 7.14% of patients. KI-67 in patients with breast cancer was up to 15% in 13.43% of patients, at 16-20% in 13.43% of patients, from 20% to 70% in 73.73% of patients. Product Description popup.authors Антоненко Юрій Віталійович Бугайцов Сергій Георгійович Поліщук Валентин Віталійович Шахрай Галина Федорівна popup.nrat_date 2020-04-02 Close