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Information × Registration Number 0219U004000, 0116U004300 , R & D reports Title To investigate impaired mineralization processes and collagen formation in the oral cavity during dental pathology and improved methods for early diagnosis and correction of these disorders popup.stage_title Head Denga Oksana Vasilievna, Shnaider Stanislav Arkadievich, Registration Date 19-02-2019 Organization State Establishment "The INSTITUTE of STOMATOLOGY NATIONAL ACADEMY of MEDICAL SCIENCES of UKRAINE" popup.description2 Object of study: violation of the processes of mineralization and collagen formation in various somatic pathology. Objective: to study impaired mineralization and collagen formation during fluorosis, endocrine pathology, metabolic syndrome and the development of methods for early diagnosis, treatment and prevention schemes for dental diseases. Research methods: epidemiological, clinical, experimental, molecular genetic, biochemical, biophysical. Conducted epidemiological studies in various regions of Ukraine allowed to establish a high prevalence of major dental diseases in patients with diabetes, diffuse non-toxic goiter, metabolic syndrome, the use of water with elevated concentrations of nitrates, strontium and chlorides to establish the mechanisms of damage to the oral cavity tissues complications in the oral cavity in this case is dysbiosis, increased free-radical lipid oxidation, decreased nonspecific Graphical immunity and D resistance body, reducing the total bone mineral density and quality. Experimental studies on rats in modeling fluorosis, endocrine pathology, metabolic syndrome allowed to establish the mechanisms of influence of disorders on bone and connective tissues, the structure of hard tissues of teeth, blood biochemical parameters, violation of protein and mineral metabolism, inhibition of glycosaminoglycans synthesis. Based on experimental, clinical and clinical laboratory studies, methods and complexes for the treatment and prevention of dental diseases in patients with impaired collagen formation and mineralization of the body in various somatic pathologies have been developed. Product Description popup.authors Іванов Віталій Степанович Анісімова Людмила Володимирівна Бабеня Ганна Олександрівна Ведута Оксана Павловна Всього 32 виконавця Гороховський Владислав Васильович Дєньга Анастасія Едуардівна Дєньга Едуард Михайлович Зомбор Катерина Володимирівна Колесник Каміла Олександрівна Макаренко Ольга Анатоліївна Мороз Людмила Михайлівна Ніколаєва Ганна Володимирівна Рейзвіх Ольга Едуардівна Семенов Костянтин Арнольдович Скиба Олександра Василівна Ткаченко Євгенія Костянтинівна Фрайфельд Марія Сергійовна Хомяков Михайло Костянтинович Шварцнау Олена Геннадіївна popup.nrat_date 2020-04-02 Close