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Registration Number

0219U004547, 0116U004983 , R & D reports

Title

Substantiation, development and selection of minimally invasive surgical treatment of patients with obstructive diseases of kidneys considering the etiopathogenic mechanisms of obstruction

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Head

Savenkov Volodymyr,

Registration Date

04-09-2019

Organization

3.Kharkov national medical university

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The feasibility of using retroperitoneal and transabdominal access with the use of minilaparoscopic instruments in patients with hydronephrosis due to nephroptosis is scientifically substantiated. The concept of the choice of the surgical method in the treatment of patients with terminal hydronephrosis with the consideration of clinical course characteristics is created. Diagnostic markers have been determined on the basis of expanding representations about the etiopathogenesis of hydronephrosis and urolithiasis. Deepened and expanded existing perceptions about the etiopathogenesis of hydronephrosis in view of the imbalance between different types of collagen, morphological changes in the tissues of the kidneys and the bowl-urea segment (MCC) and the content of intercellular adhesion molecules in patients with different course of the disease. The coefficient of collagen unbalance and parenchymatous-stromal coefficient of tissue of the kidneys and MCC are suggested, which allow to predict the severity of the course of hydronephrosis, acquired or congenital nature of violations that led to the development of stricture, and the probability of occurrence of recurrences. New and improved existing methods of minimally invasive surgical treatment of patients with the consideration of the etiopathogenetic mechanisms of obstruction have been developed and the concept of their application has been developed, as well as algorithms of examination and choice of surgical tactics; method of preventing recurrence of strictures; metaphysics measures are optimized. The wording of the principles of conducting patients with obstructive kidney diseases is taken into account taking into account the clinical form.

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Земляніцина Ольга Вячеславівна
Колупаєв Сергій Михайлович
Левченко Дмитро Анатолійович
Міхнов Дмитро Кондратович
Мальцев Андрій Володимирович
Ткаченко Лідія Василівна
Юхимчук Євгеній Володимирович

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2020-04-02