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Information × Registration Number 0219U006169, 0117U003926 , R & D reports Title Molecular genetic and morphological features of of lower limb tissues regeneration under conditions of chronic hyperglycemia popup.stage_title Head Dubovyk Yevhen, Registration Date 15-04-2019 Organization Sumy State University popup.description2 It has been established for the first time that the K121Q polymorphism of the ENPP1 gene is associated with type-2 diabetes development (D2) in Ukraine Population (Р = 0,050). The risk of D2 is 1,4 times higher in the bearers of the Q-allele than in the homozygotes for the main K-allele (Р = 0,027). It has been shown that the risk increases in the patients with ІМТ ? 25 kg/m2. Furthermore, it has been found for the first time the link of polymorphic site rs997509 of ENPP1 gene with development of D2 in Ukraine Population (Р = 0,015). The mathematical analysis showed that the risk of getting sick is 2,1 times higher in the bearers of the minor T-allele than in the persons who are homozygotes for the main allele (Р = 0,027). At the same time, a significant difference in the distribution of genotypes by rs997509 polymorphism of the ENPP1 gene among obese subjects in the group of diabetes and control was established (Р = 0,024). It has been revealed that the risk of type 2 diabetes development is much higher in persons with obesity who are carriers of a minor T-allele than in the homozygotes for the main C-allele (OR = 3,230; Р = 0,023). The associations of the studied polymorphic sites of the VEGF-A and BGLAP genes with the development of D2 in the Ukraine population were not detected. It has been established that a decrease in the content of K, Ca, Zn, Fe and Cu is observed in the skeletal muscles of rats with chronic hyperglycemia compared with animals without disturbances of carbohydrate metabolism. Product Description popup.authors Годовас Д.В. Даниленко М.І. Дубовик Є.І. Кір'ян В.О. Максимова О.С. Марченко І.В. Муравський Д.В. Мчедлішвілі Н.С. Пастухова К.О. Тимошенко О.О. Фоменко І.Г. Чумаченко Я.Д. popup.nrat_date 2020-04-02 Close